8:00am - 7:00pm

Atendee registration and meeting material pickup

6:30pm - 7:30pm

Opening ceremony - Solemnity Session

7:30pm - 8:30pm

Musical perfomance: Maurício Tizumba e Guardas de Congado

8:30pm

Fraternization with typical food from the State of Minas Gerais, Brazil

Integrated Conference

The BABY HUG Project

Chairs

Marcos Borato Viana (State of Minas Gerais, Brazil)
Jane Hankins (United States of America)

08:15am - 09:30am

The BABY HUG Project (Pediatric Hydroxyurea Phase III Clinical Trial): preliminary results (30’)

Winfred C. Wang (United States of America)

The BABY HUG Project (Pediatric Hydroxyurea Phase III Clinical Trial): intellectual capacity and psychological aspects (30’)

Daniel Armstrong (United States of America)

Discussion (15´)

Integrated Conference

Cellular therapy and blood centers

Chairs

Anna Bárbara de F. C. Proietti (State of Minas Gerais, Brazil)
Armando Alves da Fonseca (State of Rio de Janeiro, Brazil)

08:15am - 09:30am

Hematopoietic stem cell transplantation for the hemoglobinopathies (30')

Vanderson Rocha (France)

Blood centers and hematopoietic stem cell therapy for sickle cell disease (30')

Júnia Guimarães Mourão Cioffi (State of Minas Gerais, Brazil)

Discussion (15´)

Integrated Conference

Sickle cell disease in Brazil and in the Pan-American context

Chair

Guilherme Genovez (Ministry of Health of Brazil)

09:30am - 10:30am

Current state of the Brazilian Program for Sickle Cell Disease and efforts towards international cooperation

Joice Aragão de Jesus (Ministry of Health of Brazil)

Sickle cell disease the Pan-American context

Cristina Torres Parodi (Pan American Health Organization)

Round Table

Sickle cell disease in childhood and adolescence (1)

Chairs

Winfred C. Wang (United States of America)
Ana Paula Pinheiro C. Fernandes (State of Minas Gerais, Brazil)

10:50am - 12:30pm

Pediatric sickle cell problems related to behavior, intellectual performance and family dynamics (20’)

Daniel Armstrong (United States of America)

Neurological damage in children with
sickle cell disease (20’)

Jane Hankins (United States of America)

Transcranial Doppler ultrasonography in sickle cell disease: implementation in the public health network and cost-benefit analysis (20’)

Célia Maria Silva (State of Minas Gerais, Brazil)

Mortality from acute splenic sequestration and the organization of health care assistance (20')

Paulo do Val Rezende (State of Minas Gerais, Brazil)

Discussion (20´)

Round Table

Efforts towards international cooperation for sickle cell disease

Chairs

Kwaku Ohene-Frempong (United States of America / Ghana)
Nelci Caixeta (Federal District, Brazil)

10:50am - 12:30pm

International network for the study of sickle cell disease (20’)

Alvin Zipursky (Canada)

Sickle cell disease in the Caribbean and the international collaboration

Marvin Reid (Jamaica)

Cooperation between Brazil and West African countries (20’)

José Nelio Januario (State of Minas Gerais, Brazil)

Sickle cell disease in France and the international collaboration (20’)

Jacques Elion (France)

Discussion (20´)

Integrated Conference

Stroke: preventive and
therapeutic aspects

Chairs

Marilda de Souza Gonçalves (State of Bahia, Brazil)
Cláudia Maria Franco Ribeiro (State of Minas Gerais, Brazil)

2:00pm - 3:15pm

Erythrocytapheresis (exchange transfusion) to prevent iron overload in patients with sickle cell disease

Haewon C. Kim (United States of America)

Transfusional Safety and sickle cell disease on the Brazilian Policy of Blood and Blood Derivatives (30')

Guilherme Genovez (Ministry of Health of Brazil)

Discussion (15´)

Integrated Conference

Pulmonary hypertension and vasculopathy

Chairs

Cândida Maria Moreira Horta (State of Minas Gerais, Brazil)
Alberto Barceló (Pan American Health Organization)

2:00pm - 3:15pm

Pulmonary hypertension in sickle cell disease (30’)

Rodolfo Delfini Cançado (State of Sao Paulo, Brazil)

Sickle cell disease-specific vasculopathy (30')

Lewis Hsu (United States of America)

Discussion (15´)

Round Table

Sickle cell disease and care levels: responsibilities within the context of the Brazilian Universal Health System (SUS) and patients’ rights concerning work, education and social security

Chairs

Carlos Dalton Machado (State of Minas Gerais, Brazil)
Fátima de Oliveira (State of Minas Gerais, Brazil)

3:35pm - 5:15pm

Primary and secondary health care for patients with sickle cell disease: discrepancies and overcoming problems (20’)

Ana Paula Pinheiro Chagas Fernandes (State of Minas Gerais, Brazil)

Self-care in sickle cell disease: progress
or oversimplification? (20')

Paulo Ivo C. Araújo (State of Rio de Janeiro, Brazil)

Health care and organization of services for sickle cell disease emergencies (20’)

Cecília Maria Izidoro Pinto (State of Rio de Janeiro, Brazil)

Resolutions from the National Forum for Integrated Policies on Health Care for Persons with Sickle Cell Disease: How far have we come? (20')

Valéria de Abreu e Silva (State of Minas Gerais, Brazil)

Discussion (20´)

Round Table

Sickle cell disease in adults (1)

Chairs

Clenize das Graças C. R. Borges (State of Minas Gerais, Brazil)
Ivan de Lucena Ângulo (State of Sao Paulo, Brazil)

3:35pm - 5:15pm

Transcranial Doppler ultrasonography in adults (20')

Maria Stella Figueiredo (State of Sao Paulo, Brazil)

Recent progress in the treatment of leg ulcers (20')

Águeda Glória Sabino de Matos (State of Rio de Janeiro, Brazil)

Special aspects in the treatment of adults with sickle cell disease (20')

Cage Johnson (United States of America)

Clinical aspects of sickle cell disease in India (20')

Dilip Kumar Patel (Índia)

Discussion (20´)

Integrated Conference

Pain and sickle cell disease

Chairs

Maria Stella Figueiredo (State of Sao Paulo, Brazil)
Marlene Cezini (State of Rio de Janeiro, Brazil)

5:15pm - 6:30pm

The PISCES Project: Epidemiological study of sickle cell disease-specific pain (30’)

Wally R. Smith (United States of America)

Pain control in sickle cell disease (30’)

Lennete Benjamin (United States of America)

Discussion (15´)

Integrated Conference

Therapeutic aspects of sickle cell disease: current trends

Chairs

Rodolfo Delfini Cançado (State of Sao Paulo, Brazil)
José Orlando Bordin (State of Sao Paulo, Brazil)

5:15pm - 6:30pm

Evolution and state of art of drug therapy for sickle cell disease (30’)

Jane Hankins (United States of America)

Guidelines of the Brazilian Consensus for bone marrow transplantation in patients with sickle cell disease (30')

Belinda Pinto Simões (State of Sao Paulo, Brazil)

Discussion (15´)

Integrated Conference

Gene and cellular therapy

Chairs

Dora Mendez del Castillo (State of Minas Gerais, Brazil)
Belinda Pinto Simões (State of Sao Paulo, Brazil)

08:15am - 09:30am

Gene therapy for hemoglobinopathies (30')

Philippe Leboulch (France)

Cellular therapy for sickle cell disease-related bone complications (30')

Philippe Hernigou (France)

Discussion (15´)

Integrated Conference

Genetic aspects and ethnic groups

Chairs

Cecília Maria G. Figueira (State of Espirito Santo, Brazil)
Ana Maria Martins (State of Sao Paulo, Brazil)

08:15am - 09:30am

Origin of the beta gene mutation and its role in disease expression (30')

Solomon F. Ofori-Acquah (United States of America)

Prognostic biomarkers for sickle cell disease (30’)

Marilda de Souza Gonçalves (State of Bahia, Brazil)

Discussion (15´)

Conference

Chair

Mohamed Cherif Rahimy (Benin)

09:30am - 10:30am

A Strategic Approach to Research in Sickle Cell Disease: The view from the US National Institutes of Health (45' for presentation / 15' for discussion)

Susan Shurin (United States of America)

Round Table

International strategies for early diagnosis of sickle cell disease

Chairs

Mauro Teixeira de Figueiredo (Ministry of Health of Brazil)
Joice Aragão de Jesus (Ministry of Health of Brazil)

10:50am - 12:30pm

The Brazilian program of newborn screening for sickle cell disease (20’)

José Nelio Januario (State of Minas Gerais, Brazil)

The North-American program of newborn screening for sickle cell disease (20’)

Hani K. Atrash (United States of America)

Initiatives and perspectives in Africa
for the early diagnosis of sickle cell disease (20’)

Leon Tshilolo (Democratic Republic of the Congo)

Newborn screening for sickle cell disease in Ghana (20’)

Kwaku Ohene-Frempong (United States of America / Ghana)

Discussion (20´)

Round Table

Sickle cell disease in adults (2)

Chairs

Maria Stella Figueiredo (State of Sao Paulo, Brazil)
Roshni Kulkarni (United States of America)

10:50am - 12:30pm

Kidney injury in sickle cell disease (20’)

Sara Teresinha Olalla Saad (State of Sao Paulo, Brazil)

Liver injury in sickle cell disease (20’)

Cage Johnson (United States of America)

Challenges for the treatment of adolescent and adults with sickle cell disease in the United States (20’)

Lanetta Jordan (United States of America)

Iron overload in sickle cell disease and thalassemia in Latin America: analysis and recommendations (20’)

Aderson da Silva Araújo (State of Pernambuco, Brazil)

Discussion (20´)

Integrated Conference

Pregnancy in women with sickle cell disease

Chairs

Marília Alvares Rugani (State of Rio de Janeiro, Brazil)
Cláudia Maria Franco Ribeiro (State of Minas Gerais, Brazil)

2:00pm - 3:15pm

Clinical course and complications of sickle cell disease in pregnancy (30’)

Vanessa Fenelon Costa (State of Minas Gerais, Brazil)

Taking care of pregnant women with sickle cell disease: The Aninha Project (30’)

Milza Cintra Januário (State of Minas Gerais, Brazil)

Discussion (15´)

Integrated Conference

Laboratory diagnosis of sickle cell disease

Chairs

Paulo César Naoum (State of Sao Paulo, Brazil)
Tânia Marini de Carvalho (State of Sao Paulo, Brazil)

02:00pm - 03:15pm

Reference laboratory for hemoglobinopathies: The California Newborn Screening Program - USA (30')

Carolyn Hoppe (United States of America)

Critical analysis of techniques for the laboratory diagnosis of hemoglobinopathies (30’)

Cláudia Regina Bonini Domingos (State of Sao Paulo, Brazil)

Discussion (15´)

3:35pm - 5:20pm

Oral presentations of selected abstracts (105´)

Chairs

Josefina Aparecida Pellegrini Braga (State of Sao Paulo, Brazil)

Nivia Maria Moreira Chagas (State of Bahia, Brazil)

3:35pm - 5:20pm

Oral presentations of selected abstracts (105´)

Chairs

Solomon F. Ofori-Acquah (United States of America)

Silma Maria Alves de Melo (Ministry of Health of Brazil)

3:35pm - 5:20pm

Oral presentations of selected abstracts (105´)

Chairs

Rosângela Figueiredo (State of Minas Gerais, Brazil)

Rosângela Carrusca Alvim (State of Minas Gerais, Brazil)

3:35pm - 5:20pm

Oral presentations of selected abstracts (105´)

Chairs

Paulo Ivo Cortez de Araújo (State of Rio de Janeiro, Brazil)

Marina Lobato Martins (State of Minas Gerais, Brazil)

Integrated Conference

Emergencies in sickle cell disease

Chairs

Diagne Ibrahima (Senegal)
Aderson da Silva Araújo (State of Pernambuco, Brazil)

5:20pm - 6:35pm

Emergency care delivery for children
with sickle cell diseases and blood transfusion (30')

Kim Smith-Whitley (United States of America)

Daily aspects of emergency care delivery for adults with sickle cell disease (30')

Pat Corley (United States of America)

Discussion (15´)

Integrated Conference

Human reproduction and maturation in patients with sickle cell disease

Chairs

Marta Alice Venâncio Romanini (State of Minas Gerais, Brazil)
Leonardo Ferreira Soares (State of Piauí, Brazil)

5:20pm - 6:35pm

Human reproduction and sickle cell disease (30’)

Regina Amélia Lopes Pessoa de Aguiar (State of Minas Gerais, Brazil)

Maturation and sexual function in sickle cell disease (30’)

Paulo Roberto Juliano Martins (State of Minas Gerais, Brazil)

Discussion (15´)

Round Table

Sickle cell disease in childhood and adolescents (2)

Chairs

Jorge David Aivazoglu Carneiro (State of Sao Paulo, Brazil)
Sérgio Coelho Gomes (State of Rio de Janeiro, Brazil)

08:15am - 09:35am

Use of hydroxyurea in the treatment of children: The Brazilian experience (20’)

Clarisse Lopes de Castro Lobo (State of Rio de
Janeiro, Brazil)

The adolescent with sickle cell disease (20’)

Rosana Vilela (State of Alagoas, Brazil)

Breaking taboos: The "Camping Moon" experience for youths with sickle cell disease in California - USA (20´)

Pat Corley (United States of America)

Discussion (20´)

Round Table

Laboratory and experimental aspects
of hemoglobinopathies

Chairs

Cláudia Regina Bonini Domingos (State of Sao Paulo, Brazil)
Marvin Reid (Jamaica)

08:15am - 09:35am

Animal models of sickle cell disease (20')

Lewis Hsu (United States of America)

Co-inheritance of alpha-thalassemia
and sickle cell disease (20’)

Cibele Velloso Rodrigues (State of Minas Gerais, Brazil)

Hemoglobin variants in newborn
screening in Minas Gerais (20’)

Marcos Borato Viana (State of Minas Gerais, Brazil)

Discussion (20´)

Round Table

Sickle cell disease: controversies and special situations

Chairs

Walter Rodriguez (Costa Rica)
Miranete Arruda Rufino (State of Pernambuco, Brazil)

09:35am - 10:55am

Cellular therapy for necrosis of the
femoral head (20’)

Gildásio de Cerqueira Daltro (State of Bahia, Brazil)

Controversies in iron supplementation for children with sickle cell disease (20’)

Rocksane de Carvalho Norton (State of Minas Gerais, Brazil)

Correction of the dental arch and respiratory infection in sickle cell
disease (20´)

Wellington Espírito Santo Cavalcanti (State of Rio de Janeiro, Brazil)

Discussion (20´)

Round Table

Sickle cell disease and community programs: Experiences and dilemmas

Chairs

Berenice Assumpção Kikuchi (State of Sao Paulo, Brazil)
Maria Cândida Alencar de Queiroz (State of Bahia, Brazil)

09:35am - 10:55am

The international movement for persons with sickle cell disease (20’)

Edwige Ebakisse Badassou (France)

Social organizations for persons with sickle cell disease: The Brazilian experience (20’)

Altair dos Santos Lira (State of Bahia, Brazil)

Social organization and the sickle cell disease-specific national policy in the USA (20´)

Lanetta Jordan (United States of America)

Discussion (20´)

Conference

Chair

Isaac Odame (Canada)

11:40am - 12:10pm

The international panorama of sickle cell disease and perspectives on international collaboration (30’)

Kwaku Ohene-Frempong (United States of America / Ghana)

12:10pm - 12:40pm

Award ceremony and notices for the next Symposium (30´)

Conference

Chair

Clarisse Lopes de Castro Lobo (Rio de Janeiro)

12:40pm - 1:10pm

The transcranial Doppler ultrasonography and the future of stroke in sickle cell disease (30’)

Françoise Bernaudin (France)

Conference

Chair

Mitiko Murao (Minas Gerais)

1:10pm - 1:40pm

Transplantation of cord blood cells for the treatment of hemoglobinopathies (30’)

Carolyn Hoppe (United States of America)